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Actos Lawsuit News – 5/8/2012: Actos Lawsuit side effects are being investigated by law firms that focus on pharmaceutical and medical device litigation. If you were prescribed Actos Lawsuit and later suffered serious negative side effects please contact us today so that we can arrange a free legal consultation about potentially recovering money damages for you injuries.

Actos Lawsuit: The United States Food and Drug Administration issued a Safety Announcement on June 15th 2011 warning the public about a link between the drug Actos and Bladder Cancer. This warning has led to the investigation of a new Actos Lawsuit by attorneys across the United States. This is not the first type of Actos Lawsuit that has been investigated and filed on behalf of people who have been injured by the use of Actos. This latest Actos Lawsuit centers around the link between Actos and Bladder Cancer. If you took Actos and later developed Bladder Cancer please contact us today so that we can make arrangements for a free consultation with an Actos Attorney regarding your potential Actos Lawsuit.

When an individual has diffuse, high grade cancer of the bladder, even when superficial, bladder removal may be warranted. Many may have widespread carcinoma in situ (CIS) in conjunction with papillary disease. One can expect a high rate of recurrence and a high rate of progression to invasive disease. Generally, intravesical therapy is tried first. If this therapy is unsuccessful, repeated therapy or alternate intravesical therapies can be tried. However, with failure of intravesical therapy, further trials may prove to be equally ineffective and lead to unnecessary delay for potentially definitive curative therapy. Many recommend removal of the bladder if two courses of six weeks of BCG are ineffective. Therefore, radical cystectomy is a treatment option for any individual who is thought to be at significant risk for progression to musclc invasive and potentially metastatic disease.

For individuals with recurrent disease despite tumor removal and intravesical therapy, progression to a more serious, muscle invasive disease is common. The patient at high risk for progression must consider radical cystectomy. If the individual is not a candidate for radical cystectomy because of poor health or the individual refuses cystectomy, radiation therapy can be considered. There are no good studies available and it is difficult to assess the efficacy of radiation alone since it is always combined with TURBT and the completeness of tumor resection is an uncertain variable. In general, radiation plays a minimal role in the treatment of superficial bladder cancer.

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Actos Lawsuit: For those individuals whose bladder tumors are at high risk for recurrence or progression, instillation of agents directly into the bladder can be worthwhile. The forms of therapeutic agents come in two groups: chemotherapy or immunotherapy. It is fortunate the bladder is readily accessible to these agents, allowing for direct action with minimal systemic side effects.

Those individuals at high risk for recurrence and or progression should be considered for this therapy. Individuals with multiple or diffuse superficial tumors, large tumors, high grade tumors, superficially invasive tumors, those with recurrence within one year, or individuals with CIS all should be considered for this treatment. In addition, those with positive cytology after resection or patients with persistent superficial tumors which could not be removed should also be considered.

The agent is passed via a catheter into the bladder. The passage of the catheter generally takes just a few seconds in a woman, and perhaps ten seconds in a man. The urethral meatus (the outermost part of the urethra) is first cleansed with an antiseptic solution and then the catheter, which is made slippery with a sterile lubricant, is inserted up the urethra and into the bladder. On passage of the catheter, there is minor, short lived discomfort which may be reduced by an injection up the urethra with numbing medication. The various therapeutic agents are not painful during the infusion but may cause side effects afterwards. Depending on the agent instilled, the patient is asked not to void for a period of time afterwards to allow the agent to have its maximal effect on the bladder lining.

Our use of the term or terms Actos Lawsuit is for descriptive purposes only. There is no relationship between the owners of this website and the maker of the product discussed in this post. Our use of the words Recall, Class Action Lawsuit and other similar words related to an event do not necessarily mean that this event has occurred. Refer to the website of the United States Food and Drug Administration for information on drug or medical device recalls. If a Class Action Lawsuit is formed in relation to the product discussed in this post we will provide that information at the time the Class Action is formed. A Class Action Lawsuit is not required to exist for you to file a lawsuit if you have been injured by the product discussed in this post.

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Actos Lawsuit

Actos Lawsuit: The safety announcement from the FDA included the following excerpt: The U.S. Food and Drug Administration (FDA) is informing the public that use of the diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer. Information about this risk will be added to the Warnings and Precautions section of the label for pioglitazone-containing medicines. The patient Medication Guide for these medicines will also be revised to include information on the risk of bladder cancer.

The rigid cystoscope, although easy to pass in a female is difficult to pass without sedation in a male. The rigid cystoscope allows for generous biopsy specimens and removal of small tumors. Cystoscopy therefore can provide for both diagnosis and treatment at the same time. If a large cancer is found, removal with a resectoscope can be used to remove it at the same time. If multiple biopsies or resection of a cancer is done, spinal or general anesthesia may be required. Since rigid cystoscopy generally causes more discomfort than flexible cystoscopy and requires more anesthetic, you can expect to be out of work at least one day. In addition, someone will need to drive you home from the surgicenter or hospital.

If you are being initially screened for asymptomatic microscopic hematuria, a urologist will often choose flexible cystoscopy as the first step. He is not certain whether or not you have a bladder cancer or other condition causing the hematuria. Flexible cystoscopy will provide that answer in a less time consuming, less painful and more cost effective way than rigid cystoscopy. On the other hand, if there is a high likelihood a tumor is present, it makes sense to do rigid cystoscopy and if required, resection all at one setting. If you are experiencing gross hematuria, flexible cystoscopy does not provide adequate visualization, and rigid cystoscopy is warranted. Many urologists use both types of cystoscopes, but some do not have the flexible cystoscope in their office

Actos Lawsuit

Actos Lawsuit: The safety announcement from the FDA included the following excerpt: The U.S. Food and Drug Administration (FDA) is informing the public that use of the diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer. Information about this risk will be added to the Warnings and Precautions section of the label for pioglitazone-containing medicines. The patient Medication Guide for these medicines will also be revised to include information on the risk of bladder cancer.

Although there have been clusters of bladder cancer reported, most researchers believe these may be secondary to risk factors such as smoking and exposure to carcinogens. At this time, there is no convincing evidence bladder cancer risk is hereditary. If an environmental factor caused your cancer and your children are exposed as well, their risk of cancer may be increased. The basic building block of the body is the cell. Cells are specialized to perform a particular function. Skin cells are distinctly different from liver cells which are different from bladder cells. An organ is composed of various cells working in unison to carry out a body function. Cells eventually get old and die. New cells are created by cell division. When cells are behaving normally, they only generate enough new cells to replace the old dying ones. Occasionally, cell growth becomes unchecked. As the cells continue to divide, a tumor (abnormal growth of cells) may form. Such tumors may be benign (no ability to spread beyond their organ of origin) or cancerous (a malignant tumor with the ability to spread beyond their organ of origin and cause harm and possibly death).

Actos Lawsuit

Actos Lawsuit: Intravenous pyelogram (IVP) is accomplished by injecting a contrast agent into your vein and then obtaining X ray images. The contrast is excreted by your kidneys, subsequently filling the lumen of the kidneys, ureters and the bladder. The contrast allows one to see subtle filling defects within chambers of the urinary tract, possibly representing tumor, stone or blood clot. Tumors of the fleshy part of the kidneys can also be seen. The study also allows for an assessment of renal function. It is a sensitive test for renal obstruction, which can occur because of cancer. Disadvantages of the study include the possibility of an IV contrast agent allergy, which occasionally may be serious.

You will be asked whether you have a sea food allergy, a known allergy to iodine or to IV contrast. If this is the case, you may need to be premedicated prior to the exam to avoid a reaction. Although the study is quite useful at visualizing the upper tracts, it is not very good at picking up subtle tumors on the bladder surface. If your kidneys do not function well (you have renal insufficiency), the contrast may cause harm to your kidneys and the imaging will not be as good. For pregnant women, any X ray exam could be potentially damaging to the fetus and therefore, will not be performed. Ultrasonography can check for a kidney tumor, stone, or obstruction. Bladders filled with urine can be scanned. There is no contrast or X rays involved, and therefore the study can be accomplished in those with renal disease, contrast allergies or for women who are pregnant. Although larger tumors of the bladder are often visible, it is not a good study to rule out urothelial cancer (transitional cell cancer of the urinary tract lining) since smaller tumors or flat tumors in the lining are not visible. Also, other conditions such as enlarged folds in the bladder or enlarged prostates can be confused with bladder tumors. Ultrasound exams are generally fast, painless, and relatively inexpensive. An ultrasound combined with cystoscopy plus cytology (to rule out cancer cells) is a reasonable assessment for those with a low likelihood of having upper tract disease.

Our use of the term or terms Actos Lawsuit is for descriptive purposes only. There is no relationship between the owners of this website and the maker of the product discussed in this post. Our use of the words Recall, Class Action Lawsuit and other similar words related to an event do not necessarily mean that this event has occurred. Refer to the website of the United States Food and Drug Administration for information on drug or medical device recalls. If a Class Action Lawsuit is formed in relation to the product discussed in this post we will provide that information at the time the Class Action is formed. A Class Action Lawsuit is not required to exist for you to file a lawsuit if you have been injured by the product discussed in this post.

Actos Lawsuit

Actos Lawsuit: The United States Food and Drug Administration issued a Safety Announcement on June 15th 2011 warning the public about a link between the drug Actos and Bladder Cancer. This warning has led to the investigation of a new Actos Lawsuit by attorneys across the United States. This is not the first type of Actos Lawsuit that has been investigated and filed on behalf of people who have been injured by the use of Actos. This latest Actos Lawsuit centers around the link between Actos and Bladder Cancer. If you took Actos and later developed Bladder Cancer please contact us today so that we can make arrangements for a free consultation with an Actos Attorney regarding your potential Actos Lawsuit.

Approximately three quarters of individuals with bladder cancer initially present with blood in their urine. The blood may be visible to the naked eye (gross hematuria), or seen with a microscope only (microscopic hematuria). In the case of gross hematuria secondary to bladder cancer, it is often total (throughout the entire stream) and may be intermittent. Generally, there is no pain associated with it. I have seen many patients over the years who had gross hematuria months earlier who falsely assumed their condition was not serious since the bleeding stopped and there was no pain, only to come in later with recurrent bleeding, their tumors needlessly more advanced. When an individual experiences gross hematuria, a work up is a must! Gross hematuria at times can become quite severe to the point blood clots can restrict the flow of urine. What could have been an elective assessment then becomes a mad dash to the emergency room for catheterization (passing a tube into the bladder) and irrigation or an emergency procedure. Of course, there are other causes for gross hematuria, such as urinary infections, kidney stones or tumors in the kidney, all of which require assessment.

If a urine dipstick is positive for blood, it is recommended to check the urine under a microscope. The urine is first spun down to separate out the sediment and is then examined under the high power lens. If there are more than 3 red blood cells per high power field it is felt to be significant. If there are no other reasons for the presence of blood such as a urinary infection, the urine should be rechecked. If there is a persistent presence of significant microscopic hematuria, an assessment is recommended. When there is a large amount of microscopic hematuria, especially in older individuals with risk factors for bladder cancer, there is no need to repeat the urinalysis as a workup should be done.

Actos Lawsuit